Overview
SCIENTIFIC SCORE
Questionable
Based on 6 Researches
6.3
USERS' SCORE
Good
Based on 23 Reviews
8
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin K₂ (as MK-7 [Menaquinone-7])
90 mcg
†
Top Medical Research Studies
9
Vitamin K1 reduces coronary calcifications
We aimed to determine how vitamin K1 affects coronary artery calcifications in patients undergoing hemodialysis. In our study with 60 participants, we compared the effects of intravenous vitamin K1 against a placebo over 12 months.
The results showed that vitamin K1 significantly slowed the progression of coronary artery calcifications by 55%, compared to the placebo group. This finding suggests vitamin K1 may offer an important benefit in managing heart health for those with chronic kidney disease.
The results showed that vitamin K1 significantly slowed the progression of coronary artery calcifications by 55%, compared to the placebo group. This finding suggests vitamin K1 may offer an important benefit in managing heart health for those with chronic kidney disease.
Read More
7
Real-world effectiveness of blood thinners
We explored how well the outcomes of landmark trials for two blood thinners—apixaban and rivaroxaban—hold up in real-world atrial fibrillation (AF) patients. By examining data from the GARFIELD-AF registry, we found that patients on these treatments had similar results in preventing strokes, bleeding, and overall mortality when compared to those on vitamin K antagonists.
While apixaban showed promising results, rivaroxaban had more mixed findings, yet overall, the effectiveness and safety were largely in line with the original trials. This suggests that these medications can be appropriately used in everyday medical practice.
While apixaban showed promising results, rivaroxaban had more mixed findings, yet overall, the effectiveness and safety were largely in line with the original trials. This suggests that these medications can be appropriately used in everyday medical practice.
Read More
4
Vitamin K antagonists raise mortality risk
We analyzed data from a study involving patients who underwent mitral valve repair and had atrial fibrillation, comparing the effects of direct oral anticoagulants to vitamin K antagonists (VKAs).
Surprisingly, we found that both treatments led to similar rates of serious complications, like strokes or bleeding. However, those on VKAs showed a significantly higher overall mortality. This suggests that while both anticoagulants may work similarly for immediate outcomes, VKAs might come with increased risks for longer-term survival. Further research is needed to clarify the best options for these patients.
Surprisingly, we found that both treatments led to similar rates of serious complications, like strokes or bleeding. However, those on VKAs showed a significantly higher overall mortality. This suggests that while both anticoagulants may work similarly for immediate outcomes, VKAs might come with increased risks for longer-term survival. Further research is needed to clarify the best options for these patients.
Read More
Most Useful Reviews
9
Cleans arteries effectively
8 people found this helpful
This product has been excellent for cleaning arteries. After starting it, my husband had a check-up and his doctor remarked on how perfect his EKG results were. His blood pressure is also stabilising, and he only takes one capsule daily, occasionally skipping days.
Read More
9
Restores calcium metabolism
2 people found this helpful
I prescribed this to a patient aiming to restore calcium metabolism, and it successfully removed calcifications, as confirmed by ultrasound. I take it with D3 regularly, although it requires many capsules.
Read More
9
Heart disease risk
2 people found this helpful
Vitamin K2 has been pivotal in reducing calcium plaque in my arteries, thus lowering my heart disease risk. I won’t be without it, as it’s an essential supplement that deserves more recognition.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 6 Researches
6.3
- All Researches
9
Vitamin K1 reduces coronary calcifications
We aimed to determine how vitamin K1 affects coronary artery calcifications in patients undergoing hemodialysis. In our study with 60 participants, we compared the effects of intravenous vitamin K1 against a placebo over 12 months.
The results showed that vitamin K1 significantly slowed the progression of coronary artery calcifications by 55%, compared to the placebo group. This finding suggests vitamin K1 may offer an important benefit in managing heart health for those with chronic kidney disease.
The results showed that vitamin K1 significantly slowed the progression of coronary artery calcifications by 55%, compared to the placebo group. This finding suggests vitamin K1 may offer an important benefit in managing heart health for those with chronic kidney disease.
Read More
9
We analyzed a study comparing two anticoagulation options—direct oral anticoagulants (DOACs) and vitamin K antagonists (VKAs)—in patients with non-valvular atrial fibrillation who faced blood clots despite previous treatment.
Our findings reveal that those on DOACs had significantly fewer cardioembolic events and complications following left atrial appendage closure.
In contrast, patients on VKAs did not show the same benefit, which suggests that DOACs may be a more effective option for ongoing treatment in these cases.
Our findings reveal that those on DOACs had significantly fewer cardioembolic events and complications following left atrial appendage closure.
In contrast, patients on VKAs did not show the same benefit, which suggests that DOACs may be a more effective option for ongoing treatment in these cases.
Read More
7
Real-world effectiveness of blood thinners
We explored how well the outcomes of landmark trials for two blood thinners—apixaban and rivaroxaban—hold up in real-world atrial fibrillation (AF) patients. By examining data from the GARFIELD-AF registry, we found that patients on these treatments had similar results in preventing strokes, bleeding, and overall mortality when compared to those on vitamin K antagonists.
While apixaban showed promising results, rivaroxaban had more mixed findings, yet overall, the effectiveness and safety were largely in line with the original trials. This suggests that these medications can be appropriately used in everyday medical practice.
While apixaban showed promising results, rivaroxaban had more mixed findings, yet overall, the effectiveness and safety were largely in line with the original trials. This suggests that these medications can be appropriately used in everyday medical practice.
Read More
5
Vitamin K antagonists: outcomes assessed
We investigated the impact of vitamin K antagonists (VKA) on patients with atrial fibrillation (AF). Our study included 1,350 patients who received VKA for at least a year, tracking various outcomes like cardiovascular death and thromboembolic events.
Interestingly, while we noted predictors for these clinical outcomes—like previous thromboembolism or bleeding—no significant improvement in heart disease was directly linked to vitamin K treatment itself. Instead, factors such as age and kidney function played crucial roles in determining patient outcomes.
Interestingly, while we noted predictors for these clinical outcomes—like previous thromboembolism or bleeding—no significant improvement in heart disease was directly linked to vitamin K treatment itself. Instead, factors such as age and kidney function played crucial roles in determining patient outcomes.
Read More
4
Vitamin K antagonists raise mortality risk
We analyzed data from a study involving patients who underwent mitral valve repair and had atrial fibrillation, comparing the effects of direct oral anticoagulants to vitamin K antagonists (VKAs).
Surprisingly, we found that both treatments led to similar rates of serious complications, like strokes or bleeding. However, those on VKAs showed a significantly higher overall mortality. This suggests that while both anticoagulants may work similarly for immediate outcomes, VKAs might come with increased risks for longer-term survival. Further research is needed to clarify the best options for these patients.
Surprisingly, we found that both treatments led to similar rates of serious complications, like strokes or bleeding. However, those on VKAs showed a significantly higher overall mortality. This suggests that while both anticoagulants may work similarly for immediate outcomes, VKAs might come with increased risks for longer-term survival. Further research is needed to clarify the best options for these patients.
Read More
User Reviews
USERS' SCORE
Good
Based on 23 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Cleans arteries effectively
8 people found this helpful
This product has been excellent for cleaning arteries. After starting it, my husband had a check-up and his doctor remarked on how perfect his EKG results were. His blood pressure is also stabilising, and he only takes one capsule daily, occasionally skipping days.
Read More
9
Restores calcium metabolism
2 people found this helpful
I prescribed this to a patient aiming to restore calcium metabolism, and it successfully removed calcifications, as confirmed by ultrasound. I take it with D3 regularly, although it requires many capsules.
Read More
9
Heart disease risk
2 people found this helpful
Vitamin K2 has been pivotal in reducing calcium plaque in my arteries, thus lowering my heart disease risk. I won’t be without it, as it’s an essential supplement that deserves more recognition.
Read More
9
Essential for heart
1 people found this helpful
I require this vitamin due to osteopenia. It’s crucial for those with vascular disease. While recommended doses vary, I find 90μg sufficient and trust this reputable brand.
Read More
9
Heart health support
MK-7 is instrumental in calcium metabolism, thereby reinforcing bone health and reducing heart disease risks. It also aids immune function and manages inflammation effectively.
Read More
Frequently Asked Questions
9
Cleans arteries effectively
8 people found this helpful
This product has been excellent for cleaning arteries. After starting it, my husband had a check-up and his doctor remarked on how perfect his EKG results were. His blood pressure is also stabilising, and he only takes one capsule daily, occasionally skipping days.
7.5
Supports bone health
32 people found this helpful
I used this product to help calcium absorption in my bones and found it beneficial for my heart. I've been taking it for three months, and my chiropractor noted an improvement in my spine alignment.
7.5
Directs calcium properly
I have taken it for the third time. Initially, I had 180 mg alongside hydroxyapatite, D3, and calcium. Now I take it twice with a lower dosage. Excellent supplements! Following Berg's advice, I discovered that K2 guides calcium to the teeth and bones, rather than allowing it to contribute to heart disease.
9
Restores calcium metabolism
2 people found this helpful
I prescribed this to a patient aiming to restore calcium metabolism, and it successfully removed calcifications, as confirmed by ultrasound. I take it with D3 regularly, although it requires many capsules.
9
Heart disease reduction
This product is effective in promoting bone health while reducing the risk of heart disease and stroke, plus it helps control blood sugar levels.
7.5
Cardiovascular benefits
1 people found this helpful
An excellent product that effectively reduces the risk of heart disease and positively impacts bone density.
9
Supports heart health
Great for health, it supports bone and cardiovascular health. The MK-7 form has superior bioavailability, which allows my body to absorb it effectively. Since I started taking it, I’ve experienced improvements in my vitality, and it reassures me that I'm aiding my bone density and combating heart disease. The softgels are easy to swallow, and I appreciate that the formula is free from artificial additives.
7.5
Crucial for elderly
5 people found this helpful
This vitamin is crucial with numerous benefits, particularly for heart health and arteries. It is especially necessary for the elderly, as it is safe with minimal risk of toxicity.
8
Improves arterial health
55 people found this helpful
IMPORTANT!!! When taking high doses of vitamin D3 above 5000 IU, it's crucial to take vitamin K2 MK-7. K2 helps improve artery elasticity, supports blood clotting, and reduces calcium buildup in blood vessels. This fat-soluble vitamin is essential for calcium absorption and can slow the ageing process. I recommend taking one capsule at breakfast. I appreciate your support!
7.5
Osteoporosis prevention
I take K2 alongside D3 for osteoporosis prevention and heart protection. The small capsules are easy to swallow, and I consume them with breakfast.
9
Heart disease risk
2 people found this helpful
Vitamin K2 has been pivotal in reducing calcium plaque in my arteries, thus lowering my heart disease risk. I won’t be without it, as it’s an essential supplement that deserves more recognition.
9
Essential for heart
1 people found this helpful
I require this vitamin due to osteopenia. It’s crucial for those with vascular disease. While recommended doses vary, I find 90μg sufficient and trust this reputable brand.
7.5
Convenient heart support
It supports heart health. The pill is convenient, small, and easy to swallow. I take one pill per day.
7.5
Maintains heart health
198 people found this helpful
I previously purchased this supplement in gelatin capsules and it helped maintain my heart. I noticed a positive effect; however, when I tried to increase the dosage, my heartbeat became irregular. I am grateful to IHERB and the reviewers, as their insights greatly assist in choosing supplements, given the lack of sufficient guidance from some doctors.
7.5
Lowers mortality risk
4 people found this helpful
Vitamin K aids calcium absorption, and statins reduce vitamin K levels. Therefore, taking vitamin K2 MK-7 is advisable while on statins. It decreases the risk of osteoporosis and lowers the stiffness and calcification of arteries, ultimately reducing mortality risk from heart disease.
References
- Liporace IL, Oliveira GBF, Alves LBO, Galassi NM, Jeronimo AD, et al. Incidence and Predictors of Clinical Outcomes in Patients with Valvular and Nonvalvular Atrial Fibrillation Using Vitamin K Antagonists. Arq Bras Cardiol. 2025;122:e20240147. doi:10.36660/abc.20240147
- Schipper JH, Sommer AS, Nies RJ, Metze C, Meertens MM, et al. Direct Oral Anticoagulants Versus Vitamin K Antagonists After Mitral Valve Transcatheter Edge-to-Edge Repair in Patients With Atrial Fibrillation: A Single-Center Observational Study. J Am Heart Assoc. 2025;14:e038834. doi:10.1161/JAHA.124.038834
- Babadagli HE, Ye J, Chen J, Turgeon R, Wang EH. Efficacy and safety of anti-thrombotic therapy after surgical mitral valve repair: a scoping review. Open Heart. 2025;12. doi:10.1136/openhrt-2024-003158
- Himmelreich JCL, Virdone S, Camm AJ, Pieper K, Harskamp RE, et al. Emulation of ARISTOTLE and ROCKET AF trials in real-world atrial fibrillation patients results in similar efficacy and safety as original landmark trials: insights from the GARFIELD-AF registry. Open Heart. 2025;12. doi:10.1136/openhrt-2024-002966
- Macias-Cervantes HE, Ocampo-Apolonio MA, Guardado-Mendoza R, Baron-Manzo M, Pereyra-Nobara TA, et al. Effect of vitamin K1 supplementation on coronary calcifications in hemodialysis patients: a randomized controlled trial. J Nephrol. 2025;38:511. doi:10.1007/s40620-024-02154-9
- Preda A, Falasconi G, Melillo F, Margonato D, Posteraro GA, et al. Left atrial appendage closure in patients with failure of anticoagulation therapy: A multicenter comparative study on the hybrid strategy using DOACs and VKAs. Int J Cardiol. 2025;421:132875. doi:10.1016/j.ijcard.2024.132875
